What is a double marker test in pregnancy?

A double marker test is usually recommended for pregnant women to detect chromosomal abnormalities. The test gives us the values of free beta hCG (Human Chorionic Gonadotropin) and PAPP-A (Pregnancy Associated Plasma Protein-A).
Women over 35 and those with a family history of type 1 diabetes mellitus and birth abnormalities are typically advised to get the double marker test.A double marker test is usually recommended for pregnant women to detect chromosomal abnormalities.

The test gives us the values of free beta hCG (Human Chorionic Gonadotropin) and PAPP-A (Pregnancy Associated Plasma Protein-A). Women over 35 and those with a family history of type 1 diabetes mellitus and birth abnormalities are typically advised to get the double marker test.

Difference between NT and Double marker

A nuchal Translucency scan is a safe and non-invasive procedure that uses ultrasound waves to detect any chromosomal abnormality in the baby.

It is usually done between 11 and 14 weeks of gestation. NT scan without a double marker test provides results with lesser accuracy. However, a combination of both gives 90% accurate results.

Is a double marker test done after the NT scan?

It is not required to have the double marker test and NT scan during the first trimester. However, if you are over 35 or may be at an increased risk of chromosomal abnormalities, such as if you have a family history of a particular condition, screening is advised.

It is put forth that a double marker test can be done as soon as an NT scan.

Should NT scan and double marker be done on the same day?

To use a double marker, an NT SCAN report is required. Therefore, scan first, followed a week later by a double marker. However, both help us detect chromosomal abnormality involved.

How accurate is a double marker test?

The double marker test has an accuracy of 50% on a scale of 100, which means there are another 50% chances of false results. NT scan is more accurate than the double marker test. It is said that a combined test of both will provide greater accuracy.

What is the high risk of a double marker test?

While the Double Marker test normal value for PAPP – A is 1 MoM (multiples of median) for the female gender across all age groups, the normal range of hCG for all age groups, the range for pregnant women is 25700-288000 mIU/ml.

A glycoprotein hormone called free beta hCG is created by the placenta during pregnancy. Its elevated level suggests an increased risk of Trisomy 18 and Down’s syndrome.

A crucial plasma protein is PAPP-A. The likelihood of having down syndrome is indicated by a low plasma protein level. Higher the level, the higher the risk for chromosomal abnormalities

What if the double marker test is negative?

Screen-negative in a double marker test indicates Low-risk of any chromosomal abnormalities. It is similar to the results. A low-risk result, however, doesn’t automatically imply that the baby won’t experience complications. Also noteworthy is the fact that the first-trimester screening only searches for trisomy 13, trisomy 18, and down syndrome markers.

Why is a double marker test recommended?

Why is a double marker test recommended?

A double marker test is a screening process that is usually done in the first trimester. It detects any chromosomal abnormality in the baby for earlier diagnostic purposes. It is not a mandatory one. It is mostly recommended for pregnant women above 3 years of age, with congenital family conditions, and diabetes mellitus.

What steps are involved in screening with a double marker test?

The double marker test consists of an ultrasound examination and blood test that has two markers of hCG and PAPP-A. Based on the values and the ultrasound reports the risk for chromosomal abnormality is calculated for the baby.
5/5 - (2 votes)

Leave a Reply

Your email address will not be published. Required fields are marked *

This field is required.

This field is required.